The Seven Year's War led Britain in a fragile condition that led to even more issues, the greatest being the American Revolution.
On the Economic aspect, thanks to The Navigation Acts, colonies were forbidden to trade directly,and were forced to use Britain as an intermediate to re-export. Nevertheless, this also provided the colonies a steady market and the protection of the British fleet.
On the political aspect, The colonists obtained land illegally from Native Americans, which led Britain to build a larger army to defend the colonists from the Native Americans and the French, so they thought that Colonists should at least contribute paying one third of the costs.
On the financial side,the Parliament had the right to pass the Stamp Act, imposing his taxation on the colonies as a contribution to the Army. But colonists thought that they could not be taxed internally by a Parliament in which they weren't represented.
Colonists answered to The Townshend Act of 1767 with revolts, being the most important ones "The Boston massacre" in which soldiers prevented an uprising, and the "Tea into the Sea"(1778) that helped colonists to reduced the duty on tea,orchestrated by The Sons Of Liberty.
Among the effects of the American revolution, The Articles of Confederation,though insufficient, were the first attempts to govern a nation.The Constitutional Convention consisted in overcoming the previous one to eliminate the formation of a new government.
The Federalists Papers (based on essays by Hamilton, Jay and Madison), outlined the reasons why the States should ratify a Constitution.
The Bill Of Rights, the first ten amendments to the united States, and of course, The Declaration of Independence being the most important effects, the revolution ended with the Treaty of Paris in 1783 in which Britain surrendered, but setting the path to the French to begin their own.